Time：Oct 20th(Tue.), 13:30pm-17:00pm

Venue: Rm B407, ZJUI building

Topic: Enterprise innovation and responsibility

Abstract:

Paradigm of translational research-A lesson from Leber's hereditary optic neuropathy

Speak: Prof. Min-Xin Guan

Associate Dean of Faculty of Medicine and Pharmaceutical Sciences, ZJU

A goal of biology is to predict how mutations combine to alter phenotypes, fitness and disease. It is often assumed that mutations combine additively or with interactions that can be predicted. I will describe our work showing that this assumption is incorrect. Mutations combine differently at different expression levels. Sometimes predicting how mutations combine would be impossible even with perfect measurements of the mutational effects on a trait and the mechanistic understanding of the genetic system.